Tuesday 28 April 2020

Revision: Fertilisation

Q1B - please see previous blog post for Q1A - Remember these are my revision notes and you must do your own research for accuracy.

Question:  Outline the experimental evidence for the role of one molecule in fertilisation

Baibakov et al found human sperm bind to Homo sapiens zonae pellucida but not to those of non-human primates.
Human sperm only bind to zonae pellucid with contained human ZP2.  Recognition of fertilisation within species is dependant on a N-terminal domain of ZP2.  After fertilisation degradation takes place of N-terminal ZP2 to block polyspermy.


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